new liver cancer treatment 2018

“We’ll see that phase 3 trial soon. In the second-line setting, Keytruda (pembrolizumab), another checkpoint inhibitor, is being tested. 2018: New Research and Treatments for Digestive, Liver Diseases, Initiative Created to Accelerate Drug Development, Researchers Explore Role of S-adenosylmethionine, Research Identifies Gut Gas Linked to Diarrhea, COVID-19 Update: Surge Preparedness, Vaccine Distribution, Long-Term Impacts of COVID-19: Your Mental Health, Today: The 2 Holiday Scenarios When You Should Wear a Mask at Home, Three Brothers Bond Over Shared Rare Disease, Study: TB Vaccine Linked to Lower Risk of Contracting COVID-19, Holiday Travel Tips From an Infectious Disease Specialist. A year from now, with more data in, Abou-Alfa expects that the scientific community will have more answers about whether Opdivo will best Nexavar in firstline treatment, as well as whether Imfinzi and tremelimumab, used together, will bring meaningful benefit. He is also quite hopeful about approaches to treatment that are local, rather than systemic. At the beginning of 2017, patients with inoperable hepatocellular carcinoma (HCC), or liver cancer, were hungry for novel treatments: It had been a decade since the targeted drug Nexavar (sorafenib) was approved by the Food and Drug Administration (FDA). In a phase 2 trial, 15 percent to 20 percent of patients with liver cancer responded to Opdivo, leading to its FDA approval in the second-line setting, meaning it should be used after initial treatment with a medication such as Nexavar, if needed. But when Cabometyx was studied versus placebo in a broader group of previously treated patients — those whose liver cancers expressed mutated c-MET and those whose disease was negative for the protein — the trial brought hopeful results, Abou-Alfa says. Other common side effects included pain, decreased appetite, infection, dysphonia (a voice control problem), elevated bilirubin (which can indicate a liver problem), fever, mucositis (ulceration of the lining of the digestive tract), weight loss, rash and nausea. It is ongoing, and we will see where it’s going to take us. Results released at the Gastrointestinal Cancers Symposium showed that the medication sparked a response in 16.1 percent of patients with advanced liver cancer, previously treated with Nexavar, who participated in a trial. The answers will depend on data from ongoing clinical trials on Cabometyx, Opdivo and other drugs, he says. Another TKI seems likely to be approved for the initial treatment of liver cancer, according to Abou-Alfa. Mobile Health and Food Symptom Tracker: Researchers tested a new questionnaire called the Food and Symptom Tracker (FAST) and successfully validated it against existing measures. “Creeping Fat” around intestines of IBD patients: Most Crohn’s disease patients develop what is known as “creeping fat” around sites of inflammation in the intestines. The most common serious or severe side effects with both drugs were hypertension, decreased weight, decreased platelet count, elevated aspartate aminotransferase indicating potential liver damage, decreased appetite, diarrhea and hand-foot skin reaction. “It is an impressive effort,” he continues, “but the other thing that will have a lot of potential, though we haven’t seen any data yet, will be CAR (chimeric antigen receptor)-T cell therapy.” This involves removing immune cells from patients, engineering them to recognize and kill cancer cells associated with specific proteins, and reinfusing the powerful T cells. In the trial that led to the approval, the most common serious or severe side effects associated with Stivarga were hypertension, hand-foot skin reaction, fatigue and diarrhea. It’s not yet certain whether using immunotherapies and TKIs together will improve outcomes, but the idea is on the table, Abou-Alfa says. After 10 years without a new drug for liver cancer, two approvals and a promising pipeline are changing the landscape. Abou-Alfa describes this sequencing issue as one of his biggest challenges. If all or many of these drugs get approved, scientists and doctors will be left grappling with the question of which should be used as initial treatments and which in the second line. Opdivo is an immunotherapy known as a checkpoint inhibitor because it targets a protein that would normally keep the immune system in check; this frees up the immune system to fight harder against cancer. The drug is known as a tyrosine kinase inhibitor (TKI) because it works by targeting and disabling specific cancer- driving proteins, or kinases. While this process may initially be a protective response to wounds in the intestine caused by Crohn’s, the extra fat can eventually cause fibrosis, making the disease worse. In the past, the experimental drug tivantinib, which also inhibits c-MET, did not prove effective when compared with placebo in c-MET-positive patients with liver cancer. The kinase inhibitor Cabometyx (cabozantinib), an inhibitor of the protein c-MET, looks promising for secondline treatment. Photo by Cedars-Sinai. Those data were reported during January’s annual Gastrointestinal Cancers Symposium hosted by the American Society of Clinical Oncology. If the phase 3 CheckMate-459 trial proves that Opdivo is more effective than Nexavar as a first-line treatment, and other studies also favor initial immunotherapy, patients will expect doctors to use checkpoint inhibitors as an initial treatment, pushing TKIs into the second-line setting, Abou-Alfa says, adding that there aren’t yet enough data to guess which TKIs will be used before others.. Other potential treatments are farther out on the horizon. Phase 2 trial, the most common serious or severe side effects were indicators of potential liver or damage! Patients to more accurately track their food-specific Gastrointestinal symptoms see that phase trial! Be approved for the initial treatment of liver cancer track their food-specific Gastrointestinal symptoms, unfortunately, of. Pembrolizumab ), an inhibitor of the protein c-MET, looks promising for secondline treatment seems likely to approved!, this year has been quite impressive. ”, however, this year has been quite ”... 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